Publications

Recent Preprints

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Cendon CC, Du W, Durek P, Alexander T, Serene L, Lai T, Schulz AR, Rao A, Heinz GA,  Stefanski AL, Bruns A, Siewert K, Doerner T, Chang HD, Volk HD, Romagnani C, Mashreghi MF, KT*, Radbruch A*, Dong J*. Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction. https://doi.org/10.1101/2020.04.02.021709 (*corresponding authors)(2020).

Research articles - Systems Biology of Inflammation

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 Hammer Q, Rückert T, Borst EM, Dunst J, Haubner A, Durek P, Heinrich F, Gasparoni G, Babic M, Tomic A, Pietra G, Nienen M, Blau IW, Hofmann J, Na IK, Prinz I, Koenecke C, Hemmati P, Babel N, Arnold R, Walter J, KT, Mashreghi MF, Messerle M, Romagnani C. Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells. Nat Immunol. 19(5):453-63 (2018). 

KT, Wu LF, Altschuler SJ. Modeling Cell-to-Cell Communication Networks Using Response-Time Distributions. Cell Systems 6:355-367 (2018). 

Ramirez M, Rajaram S, Steininger RJ, Osipchuk D, Roth MA, Morinishi LS, Evans L, Ji W, Hsu CH, KT, Wei S, Zhou A, Koduru PR, Posner BA, Wu LF, Altschuler SJ. Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells. Nat Comm 7:10690 (2016) 

Diz-Muñoz A, KT, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. PLoS Biol 14(6):e1002474 (2016). 

KT, Gerecht D, Friedmann E, Höfer T. Three-Dimensional Gradients of Cytokine Signaling between T Cells. PLoS Comput Biol 11(4):e1004206 (2015). 

Research Articles - previous research projects

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KT, Herbst C, Wesener F, Koller B, Wallach T, Maier B, Kramer A, Westermark PO. Principles for circadian orchestration of metabolic pathways. Proc Natl Acad Sci USA 114(7):1572-77 (2017). 

Lück S*, Thurley K*, Thaben PF, Westermark PO. Rhythmic protein degradation shapes temporal compartmentalization. Cell Rep 9(2):741-51 (*shared first authors)(2014). 

Thurley K, Tovey SC, Moenke G, Prince VL, Meena A, Thomas AP, Skupin A, Taylor CW, Falcke M (2014). Reliable encoding of stimulus intensities within random sequences of intracellular Ca(2+) spikes. Sci Signal 7(331):ra59 (2014). 

Moenke G, Falcke M, Thurley K. Hierarchic stochastic modeling applied to intracellular Ca(2+) signals. PLoS ONE 7: e51178. (2012). 

Kevin Thurley, Ian F Smith, Stephen C Tovey, Colin W Taylor, Ian Parker, Martin Falcke. “Timescales of IP3-evoked Ca2+ spikes emerge from Ca2+ puffs only at the cellular level”.  Biophys J 101:2638-44 (2011). 

Thurley K and Falcke M. Derivation of Ca(2+) signals starting from puffs reveals that pathway function is robust against cell variability and sensitive for control. Proc Natl Acad Sci USA 108:427-432 (2011). 

 Busse D, de la Rosa M, Hobiger K, Thurley K, Flossdorf M, Scheffold A, Höfer T. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci USA 107:3058-63 (2010). 

Christine Nazaret, Margit Heiske, Kevin Thurley, Jean-Pierre Mazat. “Mitochondrial energetic metabolism: a simplified model of TCA cycle with ATP production.” J Theor Biol 258:455-64 (2009).

Review Articles

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Alexander Skupin and Kevin Thurley. “Calcium signaling: From single channels to pathways”.  Adv Exp Med Biol 740:531-51 (2012). 

 Kevin Thurley, Alexander Skupin, Rüdiger Thul, Martin Falcke. “Fundamental properties of Ca(2+) signals”. Biochim Biophys Acta 1820(8):1185-94 (2012).

 Rüdiger Thul, Kevin Thurley, Martin Falcke. “Toward a predictive model of Ca2+ puffs.” Chaos 19:037108 (2009)